課程名稱 |
近代腫瘤生物學特論Ⅱ Modern Tumor Biology Ⅱ |
開課學期 |
101-2 |
授課對象 |
醫學院 腫瘤醫學研究所 |
授課教師 |
何蓓茵 |
課號 |
Onco8014 |
課程識別碼 |
453 D0150 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期五3,4(10:20~12:10) |
上課地點 |
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備註 |
本課程中文授課,使用英文教科書。與郭遠燁、張純榮、陳美齡、歐大諒合開 總人數上限:20人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1012Onco8014 |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This course is designed to be an introductory course for those who are interested in understanding oncogenesis. The course will cover several issues including epigenetics, tumor angiogenesis, immunosurveillance, immune escape and inflammation in the process of malignant transformation. Some materials, like cell cycle and chemical carcinogenesis, will not be explained in full detail but will be reviewed briefly. Those who have taken one basic course in tumor biology and graduate students from non-oncology backgrounds are welcome. |
課程目標 |
Topics to be covered:
1. Tumor suppression genes and oncogene.
2. Transcriptional factors and tumorigenesis.
3. DNA methylation , histone modification and chromatin remodelling in cancer.
4. Angiogenesis in life, tumor and medicine.
5. Immunosurveillance and immune escape of cancer.
6. Inflammation and cancer.
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
John, M., Peter, M. H., Mark, A. I., Joe, W. G., & Craig, B. T.(2008). The Molecular Basis of Cancer. Philadelphia: Saunders Elsevier. |
評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
2/22 |
Transcriptome analysis/Early detection of cancer: molecular screening |
第2週 |
3/01 |
Screening strategies for targeted therapeutics |
第3週 |
3/08 |
Animal models: flies, fish, and yeast |
第4週 |
3/15 |
Animal models to predict anticancer efficacy |
第5週 |
3/22 |
Bioinformatics/Molecular basis of radiation therapy |
第6週 |
3/29 |
Cancer and the cellular immune response/Monoclonal antibody therapy of cancer |
第7週 |
4/05 |
春假 |
第8週 |
4/12 |
Cancer treatment-immunotherapy/Cancer-specific vaccines/Gene therapy and oncolytic viruses |
第9週 |
4/19 |
期中考 |
第10週 |
4/26 |
Phase 1 trials today/Tissue specificity and cells of origin |
第11週 |
5/03 |
Natural and acquired resistance to cancer therapies |
第12週 |
5/10 |
Hematopoietic growth factors and cytokines/RNA as a therapeutic molecule |
第13週 |
5/17 |
Cancer therapeutics/Heat shock protein 90 and the proteasome |
第14週 |
5/24 |
Cancer chemoprevention/Nutrients, hormones and gene interaction |
第15週 |
5/31 |
Lymphoma/myeloma/Molecular basis of lung cancer |
第16週 |
6/07 |
Biology of chronic and acute myeloid leukemia |
第17週 |
6/14 |
Head and neck squamous cell carcinoma/ER stress and cancer |
第18週 |
6/21 |
期末考 |
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